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It is not possible in this chapter to review comprehensively all of these studies; excellent classic and recent reviews and indeed whole books have been written about the topic, and the reader is referred to these for topics that are not included or covered in insufficient depth in this chapter (Dressler, 2002; 2006; Fraser, 1950; Goodrich, 1895; 1930; Lechner and Dressler, 1997; Principles of Developmental Genetics © 2007, Elsevier Inc.

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